Drugs to treat kidney failure
It should be pointed out that in case of renal failure, taking medication will often cause unpleasant side effects in a variety of circumstances: when reducing the secretion of the drug (accumulation of toxic metabolites); when the patient becomes sensitive to the drug; when the effectiveness of the active ingredient is reduced.
To avoid this inconvenience, the patient must undergo several thorough medical examination, where a specialist will correct any dosage of that particular drug or therapy or completely change therapy.
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Renal failure – the following are the classes of drugs most used in therapy against renal failure; The medical doctor choose the active ingredient and the dosage most suitable for the patient, based on the severity of the disease, the health status of the patient and his response to treatment.
Treatment of high blood pressure
- ERYTHROPOIETIN: epoetin (eg. EPREX ALFA, NEO-RECORMON, Binocrit, Abseamed) ERYTHROPOIETIN is used in the treatment of recombinant human erythropoietin deficiency in the context of chronic renal failure. It is recommended that the administration of 50-100 units / kg sub cutaneous; alternatively, administer the drug intravenously three times a week.
- VITAMIN D: It is recommended the administration of vitamin D and derivatives in the case of severe renal failure that requires a supplement of this vitamin.
- Alfacalcidol (eg. Diseon, Diserinal, Geniad, Dediol): to be taken orally or by intravenous injection (in 30 seconds), should be initiated at 1 g per day (the dose may be adjusted by your doctor to avoid episodes of hypercalcemia); then continue therapy by administering 0.25-1 g per day, according to the patient and the severity of the disease.
- Calcitriol (eg. Calcitriol Eg, Hsp calcitriol, Rocaltrol): for patients with hypocalcemia associated with chronic renal failure on dialysis, it is recommended to take 0.5 g (about 10 ng / kg) three times a week at the beginning of therapy; when necessary, increase the dosage of 0.25-0.5 g at intervals of 2-4 weeks.
- FUROSEMIDE (eg. Furosemide Age, LASIX, Spirofur) you can take the drug orally or parenterally. Orally, it is recommended to start treatment at a dose of 20-80 mg daily, and continuing care by increasing the dose of 20-40 mg every 6-8 hours, until the desired effect is achieved. The maximum daily dose should not exceed 600 mg. Intravenously continues, administer 0.1 mg / kg as initial dose, followed by 0.1 mg / kg or double dose every 2 hours, up to a maximum of 0.4 mg / kg per hour. Consult your doctor.
- Torsemide (eg. Demadex): take orally or intravenously 10 mg substance once daily. The duration of treatment should be determined by your doctor.
- Ethacrynic acid (eg. REOMAX, Ac etacr): This medicine is particularly indicated in case of chronic renal failure associated with hypertension. We recommend taking one tablet (50 mg) daily, in the morning after breakfast. You can also parenteral administration.
- Chelating agents indicated in cases of chronic renal failure associated with hyperphosphatemia in hemodialysis patients.
- SEVELAMER (eg. RENAGEL, tablets of 400-800 mg, Renvela, 800 mg tablets or powder 1.6 g and 2.4 g, for oral suspension). Generally, it is assumed initially a dose of 2.4 to 4.8 g per day, in three divided doses with meals. The dosage will be changed later by the physician according to the plasma concentration of phosphate.
- Aluminum hydroxide: it is an antacid containing aluminum, used in therapy as a chelating agent for the treatment of hyperphosphataemia of phosphorus in the context of chronic renal failure. The recommended dose ranges from 500 to 1000 mg / day, taken orally in 4 divided doses. Also in this case, the dosage should be modified during therapy based on the serum phosphate levels.